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Contrasting mechanisms of penile urethral formation in mouse and human.
This paper addresses the developmental mechanisms of formation of the mouse and human penile urethra and the possibility that two disparate mechanisms are at play. It has been suggested that the entire penile urethra of the mouse forms via direct canalization of the endodermal urethral plate. While this mechanism surely accounts for development of the proximal portion of the mouse penile urethra, we suggest that the distal portion of the mouse penile urethra forms via a series of epithelial fusion events. Through review of the recent literature in combination with new data, it is unlikely that the entire mouse urethra is formed from the endodermal urethral plate due in part to the fact that from E14 onward the urethral plate is not present in the distal aspect of the genital tubercle. Formation of the distal portion of the mouse urethra receives substantial contribution from the preputial swellings that form the preputial-urethral groove and subsequently the preputial-urethral canal, the later of which is subdivided by a fusion event to form the distal portion of the mouse penile urethra. Examination of human penile development also reveals comparable dual morphogenetic mechanisms. However, in the case of human, direct canalization of the urethral plate occurs in the glans, while fusion events are involved in formation of the urethra within the penile shaft, a pattern exactly opposite to that of the mouse. The highest incidence of hypospadias in humans occurs at the junction of these two different developmental mechanisms. The relevance of the mouse as a model of human hypospadias is discussed
On the Generation of Medical Question-Answer Pairs
Question answering (QA) has achieved promising progress recently. However,
answering a question in real-world scenarios like the medical domain is still
challenging, due to the requirement of external knowledge and the insufficient
quantity of high-quality training data. In the light of these challenges, we
study the task of generating medical QA pairs in this paper. With the insight
that each medical question can be considered as a sample from the latent
distribution of questions given answers, we propose an automated medical QA
pair generation framework, consisting of an unsupervised key phrase detector
that explores unstructured material for validity, and a generator that involves
a multi-pass decoder to integrate structural knowledge for diversity. A series
of experiments have been conducted on a real-world dataset collected from the
National Medical Licensing Examination of China. Both automatic evaluation and
human annotation demonstrate the effectiveness of the proposed method. Further
investigation shows that, by incorporating the generated QA pairs for training,
significant improvement in terms of accuracy can be achieved for the
examination QA system.Comment: AAAI 202
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Development of the human bladder and ureterovesical junction.
The urinary bladder collects urine from the kidneys and stores it until the appropriate moment for voiding. The trigone and ureterovesical junctions are key to bladder function, by allowing one-way passage of urine into the bladder without obstruction. Embryological development of these structures has been studied in multiple animal models as well as humans. In this report we review the existing literature on bladder development and cellular signalling with particular focus on bladder development in humans. The bladder and ureterovesical junction form primarily during the fourth to eighth weeks of gestation, and arise from the primitive urogenital sinus following subdivision of the cloaca. The bladder develops through mesenchymal-epithelial interactions between the endoderm of the urogenital sinus and mesodermal mesenchyme. Key signalling factors in bladder development include shh, TGF-β, Bmp4, and Fgfr2. A concentration gradient of shh is particularly important in development of bladder musculature, which is vital to bladder function. The ureterovesical junction forms from the interaction between the Wolffian duct and the bladder. The ureteric bud arises from the Wolffian duct and is incorporated into the developing bladder at the trigone. It was previously thought that the trigonal musculature developed primarily from the Wolffian duct, but it has been shown to develop primarily from bladder mesenchyme. Following emergence of the ureters from the Wolffian ducts, extensive epithelial remodelling brings the ureters to their final trigonal positions via vitamin A-induced apoptosis. Perturbation of this process is implicated in clinical obstruction or urine reflux. Congenital malformations include ureteric duplication and bladder exstrophy
Observation of electric current induced by optically injected spin current
A normally incident light of linear polarization injects a pure spin current
in a strip of 2-dimensional electron gas with spin-orbit coupling. We report
observation of an electric current with a butterfly-like pattern induced by
such a light shed on the vicinity of a crossbar shaped InGaAs/InAlAs quantum
well. Its light polarization dependence is the same as that of the spin
current. We attribute the observed electric current to be converted from the
optically injected spin current caused by scatterings near the crossing. Our
observation provides a realistic technique to detect spin currents, and opens a
new route to study the spin-related science and engineering in semiconductors.Comment: 15 pages, 4 figure
Gr\"obner bases of syzygies and Stanley depth
Let F. be a any free resolution of a Z^n-graded submodule of a free module
over the polynomial ring K[x_1, ..., x_n]. We show that for a suitable term
order on F., the initial module of the p'th syzygy module Z_p is generated by
terms m_ie_i where the m_i are monomials in K[x_{p+1}, ..., x_n]. Also for a
large class of free resolutions F., encompassing Eliahou-Kervaire resolutions,
we show that a Gr\"obner basis for Z_p is given by the boundaries of generators
of F_p. We apply the above to give lower bounds for the Stanley depth of the
syzygy modules Z_p, in particular showing it is at least p+1. We also show that
if I is any squarefree ideal in K[x_1, ..., x_n], the Stanley depth of I is at
least of order the square root of 2n.Comment: 13 page
Acoustic black holes from supercurrent tunneling
We present a version of acoustic black holes by using the principle of the
Josephson effect. We find that in the case two superconductors and are
separated by an insulating barrier, an acoustic black hole may be created in
the middle region between the two superconductors. We discuss in detail how to
describe an acoustic black hole in the Josephson junction and write the metric
in the langauge of the superconducting electronics. Our final results infer
that for big enough tunneling current and thickness of the junction,
experimental verification of the Hawking temperature could be possible.Comment: 15pages,1 figure, to appear in IJMP
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